Publications of Janine Knauer-Arloth

Gerstner, N.; Frohlich, A. S.; Matosin, N.; Gagliardi , M.; Cruceanu, C.; Kodel, M.; Rex-Haffner, M.; Tu, X.; Mostafavi, S.; Ziller, M. J. et al.; Binder, E. B.; Knauer-Arloth, J.: Contrasting genetic predisposition and diagnosis in psychiatric disorders: A multi-omic single-nucleus analysis of the human OFC. Science advances 11 (10), eadq2290 (2025)

Hagenberg, J.; Brueckl, T. M.; Erhart, M.; Kopf-Beck, J.; Koedel, M.; Rehawi, G.; Roeh-Karamihalev, S.; Sauer, S.; Yusupov, N.; Rex-Haffner, M. et al.; Spoormaker, V. I.; Saemann, P. G.; Binder, E. B.; Knauer-Arloth, J.: Dissecting depression symptoms: Multi-omics clustering uncovers immune-related subgroups and cell-type specific dysregulation. BRAIN BEHAVIOR AND IMMUNITY 123, pp. 353 - 369 (2025)

van Doeselaar, L.; Abromeit, A.; Stark, T.; Menegaz, D.; Ballmann, M.; Mitra, S.; Yang, H.; Rehawi, G.; Huettl, R. E.; Bordes, J. et al.; Narayan, S.; Harbich, D.; Deussing, J. M.; Rammes, G.; Czisch, M.; Knauer-Arloth, J.; Eder, M.; Lopez, J. P.; Schmidt, M. V.: FKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice. Nature communications 16 (1), 2529 (2025)

Arcego, D. M.; Buschdorf, J.-P.; O'Toole, N.; Wang, Z.; Barth, B.; Pokhvisneva, I.; Rayan, N. A.; Patel, S.; de Mendonca Filho, E. J.; Lee, P. et al.; Tan, J.; Koh, M. X.; Sim, C. M.; Parent, C.; de Lima, R. M. S.; Clappison, A.; O'Donnell, K. J.; Dalmaz, C.; Arloth, J.; Provencal, N.; Binder, E. B.; Diorio, J.; Silveira, P. P.; Meaney, M. J.: A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes. BIOLOGICAL PSYCHIATRY 95 (1), pp. 48 - 61 (2024)

Froehlich, A. S.; Gerstner, N.; Gagliardi, M.; Ködel, M.; Yusupov, N.; Matosin, N.; Czamara, D.; Sauer, S.; Roeh, S.; Murek, V. et al.; Chatzinakos, C.; Daskalakis, N. P.; Knauer-Arloth, J.; Ziller, M. J.; Binder, E. B.: Single-nucleus transcriptomic profiling of human orbitofrontal cortex reveals convergent effects of aging and psychiatric disease. NATURE NEUROSCIENCE 27, pp. 2021 - 2032 (2024)

Hagenberg, J.; Budde, M.; Pandeva, T.; Kondofersky, I.; Theis, F. J.; Schaupp, S. K.; Schulze, T. G.; Mueller, N. S.; Heilbronner, U.; Batra, R. et al.; Knauer-Arloth, J.: longmixr: a tool for robust clustering of high-dimensional cross-sectional and longitudinal variables of mixed data types. BIOINFORMATICS 40 (4), btae137 (2024)

Knauer-Arloth, J.; Hryhorzhevska, A.; Binder, E. B.: Multiomics Analysis of the Molecular Response to Glucocorticoids: Insights Into Shared Genetic Risk From Psychiatric to Medical Disorders. Biological psychiatry (2024)

Martinelli, S.; Hafner, K.; Ködel, M.; Knauer-Arloth, J.; Gassen, N. C.; Binder, E. B.: Differential Dynamics and Roles of FKBP51 Isoforms and Their Implications for Targeted Therapies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 25 (22), 12318 (2024)

Kuehnel, A.; Hagenberg, J.; Knauer-Arloth, J.; Koedel, M.; Czisch, M.; Saemann, P. G.; Binder, E. B.; Kroemer, N. B.: Stress-induced brain responses are associated with BMI in women. COMMUNICATIONS BIOLOGY 6 (1), 1031 (2023)

Matosin, N.; Arloth, J.; Czamara, D.; Edmond, K. Z.; Maitra, M.; Froehlich, A. S.; Martinelli, S.; Kaul, D.; Bartlett, R.; Curry, A. R. et al.; Gassen, N. C.; Hafner, K.; Mueller, N. S.; Worf, K.; Rehawi, G.; Nagy, C.; Halldorsdottir, T.; Cruceanu, C.; Gagliardi, M.; Gerstner, N.; Ködel, M.; Murek, V.; Ziller, M. J.; Scarr, E.; Tao, R.; Jaffe, A. E.; Arzberger, T.; Falkai, P.; Kleinmann, J. E.; Weinberger, D. R.; Mechawar, N.; Schmitt, A.; Dean, B.; Turecki, G.; Hyde, T. M.; Binder, E. B.: Associations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex. ACTA NEUROPATHOLOGICA 145 (4), pp. 439 - 459 (2023)

Penner-Goeke, S.; Bothe, M.; Rek, N.; Kreitmaier, P.; Poehlchen, D.; Kühnel, A.; Glaser, L. V.; Kaya, E.; Krontira, A.; Roeh, S. et al.; Czamara, D.; Ködel, M.; Monteserin-Garcia, J.; Diener, L.; Woelfel, B.; Sauer, S.; Rummel, C.; Riesenberg, S.; Arloth-Knauer, J.; Ziller, M.; Labeur, M.; Meijsing, S.; Binder, E. B.: High- throughput screening of glucocorticoid- induced enhancer activity reveals mechanisms of stress- related psychiatric disorders. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 120 (49), e2305773120 (2023)

Czamara, D.; Neufang, A.; Dieterle, R.; Iurato, S.; Arloth, J.; Martins, J.; Ising, M.; Binder, E. B.; Erhardt, A.: Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder. CLINICAL EPIGENETICS 14 (1), 55 (2022)

Cruceanu, C.; Dony, L.; Krontira, A. C.; Fischer, D. S.; Roeh, S.; Di Giaimo, R.; Kyrousi, C.; Kaspar, L.; Arloth, J.; Czamara, D. et al.; Gerstner, N.; Martinelli, S.; Wehner, S.; Breen, M. S.; Koedel, M.; Sauer, S.; Sportelli, V.; Rex-Haffner, M.; Cappello, S.; Theis, F. J.; Binder, E. B.: Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study. AMERICAN JOURNAL OF PSYCHIATRY 179 (5), pp. 375 - 387 (2022)

Gerstner, N.; Krontira, A. C.; Cruceanu, C.; Roeh, S.; Puetz, B.; Sauer, S.; Rex-Haffner, M.; Schmidt, M. V.; Binder, E. B.; Knauer-Arloth, J.: DiffBrainNet: Differential analyses add new insights into the response to glucocorticoids at the level of genes, networks and brain regions. NEUROBIOLOGY OF STRESS 21, 100496 (2022)

Kappelmann, N.; Arloth, J.; Georgakis, M. K.; Czamara, D.; Rost, N.; Ligthart, S.; Khandaker, G. M.; Binder, E. B.: Dissecting the Association Between Inflammation, Metabolic Dysregulation, and Specific Depressive Symptoms A Genetic Correlation and 2-Sample Mendelian Randomization Study. JAMA PSYCHIATRY 78 (2), pp. 161 - 170 (2021)

Kappelmann, N.; Czamara, D.; Rost, N.; Moser, S.; Schmoll, V.; Trastulla, L.; Stochl, J.; Lucae, S.; Binder, E. B.; Khandaker, G. M. et al.; Arloth, J.: Polygenic risk for immuno-metabolic markers and specific depressive symptoms: A multi-sample network analysis study. BRAIN BEHAVIOR AND IMMUNITY 95, pp. 256 - 268 (2021)

Moore, S. R.; Halldorsdottir, T.; Martins, J.; Lucae, S.; Mueller-Myhsok, B.; Mueller, N. S.; Piechaczek, C.; Feldmann, L.; Freisleder, F. J.; Greimel, E. et al.; Schulte-Koerne, G.; Binder, E. B.; Arloth, J.: Sex differences in the genetic regulation of the blood transcriptome response to glucocorticoid receptor activation. TRANSLATIONAL PSYCHIATRY 11 (1), 632 (2021)

Ogris, C.; Hu, Y.; Arloth, J.; Mueller, N. S.: Versatile knowledge guided network inference method for prioritizing key regulatory factors in multi-omics data. SCIENTIFIC REPORTS 11 (1), 6806 (2021)

Arloth, J.; Eraslan, G.; Andlauer, T. F. M.; Martins, J.; Iurato, S.; Kuehnel, B.; Waldenberger, M.; Frank, J.; Gold, R.; Hemmer, B. et al.; Luessi, F.; Nischwitz, S.; Paul, F.; Wiendl, H.; Gieger, C.; Heilmann-Heimbach, S.; Kacprowski, T.; Laudes, M.; Meitinger, T.; Peters, A.; Rawal, R.; Strauch, K.; Lucae, S.; Müller-Myhsok, B.; Rietschel, M.; Theis, F. J.; Binder, E. B.; Mueller, N. S.: DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning. PLOS COMPUTATIONAL BIOLOGY 16 (2), e1007616 (2020)

Provencal, N.; Arloth, J.; Cattaneo, A.; Anacker, C.; Cattane, N.; Wiechmann, T.; Roeh, S.; Koedel, M.; Klengel, T.; Czamara, D. et al.; Mueller, N. S.; Lahti, J.; Raikkonen, K.; Pariante, C. M.; Binder, E. B.: Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 117 (38), pp. 23280 - 23285 (2020)