Project Group Translational Deep Phenotyping

Florian Raabe

Our primary focus is the development of multimodal biomarkers that identify and predict disease severity and treatment response in schizophrenia spectrum disorders and depression. By identifying these biomarkers, we aim to address clinical challenges represented by the heterogeneity in the etiology and pathophysiology of mental disorders and the variety in their clinical expression and response to treatment.

Our interdisciplinary team employs cutting-edge multi-omics techniques and functional (epi)genomic approaches, integrating neuroimaging, electrophysiology, and clinical data through innovative bioinformatics to unravel the complexities of these disorders. Moreover, cellular and molecular data from neurobiological models based on patient-specific induced pluripotent stem cells (iPSCs) enrich our translational deep phenotyping approach. 

As a translational research group, our mission is to improve the clinical course and outcomes for individuals affected by mental disorders, ensuring a future where personalized and effective treatments are daily clinical practice. Therefore, we conduct prospective clinical studies to validate our hypothesis.

Feel free to join or contact us on our journey to transform mental health care through innovative research and collaboration.