Publications of Kathrin Hafner

Hartmann, J.; Bajaj, T.; Otten, J.; Klengel, C.; Ebert, T.; Gellner, A.-K.; Junglas, E.; Hafner, K.; Anderzhanova, E. A.; Tang, F. et al.; Missig, G.; Rexrode, L.; Trussell, D. T.; Li, K. X.; Pohlmann, M. L.; Mackert, S.; Geiger, T. M.; Heinz, D. E.; Lardenoije, R.; Dedic, N.; McCullough, K. M.; Prochnicki, T.; Rhomberg, T.; Martinelli, S.; Payton, A.; Robinson, A. C.; Stein, V.; Latz, E.; Carlezon Jr., W. A.; Hausch, F.; Schmidt, M. V.; Murgatroyd, C.; Berretta, S.; Klengel, T.; Pantazopoulos, H.; Ressler, K. J.; Gassen, N. C.: SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration. NATURE COMMUNICATIONS 15 (1), 2635 (2024)

Hartmann, J.; Klengel, C.; Dillmann, L. J.; Hisey, E. E.; Hafner, K.; Shukla, R.; Estruch, M. S.; Bajaj, T.; Ebert, T.; Mabbott, K. G. et al.; Rostin, L.; Philipsen, A.; Carlezon Jr, W. A.; Gisabella, B.; Mccullumsmith, R. E.; Vergis, J. M.; Klengel, T.; Daskalakis, N. P.; Pantazopoulos, H.; Gassen, N. C.; Ressler, K. J.: SKA2 enhances stress- related glucocorticoid receptor signaling through FKBP4-FKBP5 interactions in neurons. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 121 (52), e2417728121 (2024)

Martinelli, S.; Hafner, K.; Ködel, M.; Knauer-Arloth, J.; Gassen, N. C.; Binder, E. B.: Differential Dynamics and Roles of FKBP51 Isoforms and Their Implications for Targeted Therapies. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 25 (22), 12318 (2024)

Stepan, J.; Heinz, D. E.; Dethloff, F.; Wiechmann , S.; Martinelli, S.; Hafner, K.; Ebert, T.; Junglas, E.; Haeusl, A. S.; Poehlmann, M. L. et al.; Jakovcevski, M.; Pape, J. C.; Zannas, A. S.; Bajaj , T.; Hermann, A.; Ma, X.; Pavenstaedt, H.; Schmidt, M. V.; Philipsen, A.; Turck, C. W.; Deussing, J. M.; Rammes, G.; Robinson, A. C.; Payton, A.; Wehr, M. C.; Stein, V.; Murgatroyd, C.; Kremerskothen, J.; Kuster, B.; Wotjak, C. T.; Gassen, N. C.: Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice. SCIENCE SIGNALING 17 (834), eadj6603 (2024)

Matosin, N.; Arloth, J.; Czamara, D.; Edmond, K. Z.; Maitra, M.; Froehlich, A. S.; Martinelli, S.; Kaul, D.; Bartlett, R.; Curry, A. R. et al.; Gassen, N. C.; Hafner, K.; Mueller, N. S.; Worf, K.; Rehawi, G.; Nagy, C.; Halldorsdottir, T.; Cruceanu, C.; Gagliardi, M.; Gerstner, N.; Ködel, M.; Murek, V.; Ziller, M. J.; Scarr, E.; Tao, R.; Jaffe, A. E.; Arzberger, T.; Falkai, P.; Kleinmann, J. E.; Weinberger, D. R.; Mechawar, N.; Schmitt, A.; Dean, B.; Turecki, G.; Hyde, T. M.; Binder, E. B.: Associations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex. ACTA NEUROPATHOLOGICA 145 (4), pp. 439 - 459 (2023)

Hausl, A. S.; Bajaj, T.; Brix, L.; Pohlmann, M. L.; Hafner, K.; De Angelis, M.; Nagler, J.; Dethloff, F.; Balsevich, G.; Schramm, K.-W. et al.; Giavalisco, P.; Chen, A.; Schmidt, M. V.; Gassen, N. C.: Mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolism. SCIENCE ADVANCES 8 (10), eabi4797 (2022)

Stepan, J.; Heinz, D. E.; Dethloff, F.; Bajaj, T.; Zellner, A.; Hafner, K.; Wiechmann, S.; Mackert, S.; Mecdad, Y.; Rabenstein, M. et al.; Ebert, T.; Martinelli, S.; Haeusl, A. S.; Poehlmann, M. L.; Hermann, A.; Ma, X.; Pavenstaedt, H.; Schmidt, M. V.; Philipsen, A.; Turck, C. W.; Deussing, J. M.; Kuster, B.; Wehr, M. C.; Stein, V.; Kremerskothen, J.; Wotjak, C. T.; Gassen, N. C.: Hippo-released WWC1 facilitates AMPA receptor regulatory complexes for hippocampal learning. CELL REPORTS 41 (10), 111766 (2022)

Hausl, A. S.; Brix, L.; Hartmann, J.; Poehlmann, M. L.; Lopez, J. P.; Menegaz, D.; Brivio, E.; Engelhardt, C.; Roeh, S.; Bajaj, T. et al.; Rudolph, L.; Stoffel, R.; Hafner, K.; Goss, H. M.; Reul, J. M. H. M.; Deussing, J. M.; Eder, M.; Ressler, K. J.; Gassen, N. C.; Chen, A.; Schmidt, M. V.: The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice. MOLECULAR PSYCHIATRY (2021)

Ebert, T.; Heinz, D. E.; Almeida-Correa, S.; Cruz, R.; Dethloff, F.; Stark, T.; Bajaj, T.; Maurel, O. M.; Ribeiro, F. M.; Calcagnini, S. et al.; Hafner, K.; Gassen, N. C.; Turck, C. W.; Boulat, B.; Czisch, M.; Wotjak, C. T.: Myo-Inositol Levels in the Dorsal Hippocampus Serve as Glial Prognostic Marker of Mild Cognitive Impairment in Mice. FRONTIERS IN AGING NEUROSCIENCE 13, 731603 (2021)

Martinelli, S.; Anderzhanova, E.; Bajaj, T.; Wiechmann, S.; Dethloff, F.; Weckmann, K.; Heinz, D. E.; Ebert, T.; Hartmann, J.; Geiger, T. M. et al.; Doengi, M.; Hafner, K.; Poehlmann, M. L.; Jollans, L.; Philipsen, A.; Schmidt, S. V.; Schmidt, U.; Maccarrone, G.; Stein, V.; Hausch, F.; Turck, C. W.; Schmidt, M. V.; Gellner, A.-K.; Kuster, B.; Gassen, N. C.: Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion. NATURE COMMUNICATIONS 12 (1), 4643 (2021)

Gassen, N. C.; Niemeyer, D.; Muth, D.; Corman, V. M.; Martinelli, S.; Gassen, A.; Hafner, K.; Papies, J.; Moesbauer, K.; Zellner, A. et al.; Zannas, A. S.; Herrmann, A.; Holsboer, F.; Brack-Werner, R.; Boshart, M.; Mueller-Myhsok, B.; Drosten, C.; Mueller, M. A.; Rein, T.: SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection. NATURE COMMUNICATIONS 10, 5770 (2019)

Zannas, A. S.; Jia, M.; Hafner, K.; Baumert, J.; Wiechmann, T.; Pape, J. C.; Arloth, J.; Koedel, M.; Martinelli, S.; Roitman, M. et al.; Roeh, S.; Haehle, A.; Emeny, R. T.; Iurato, S.; Carrillo-Roa, T.; Lahti, J.; Raikkonen, K.; Eriksson, J. G.; Drake, A. J.; Waldenberger, M.; Wahl, S.; Kunze, S.; Lucae, S.; Bradley, B.; Gieger, C.; Hausch, F.; Smith, A. K.; Ressler, K. J.; Mueller-Myhsok, B.; Ladwig, K.-H.; Rein, T.; Gassen, N. C.; Binder, E. B.: Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-kappa B-driven inflammation and cardiovascular risk. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116 (23), pp. 11370 - 11379 (2019)

Balsevich, G.; Häusl, A. S.; Meyer, C. W.; Karamihalev, S.; Feng, X.; Pöhlmann, M.; Dournes, C.; Uribe-Marino, A.; Santarelli, S.; Labermaier, C. et al.; Hafner, K.; Mao, T.; Breitsamer, M.; Theodoropoulou, M.; Namendorf, C.; Uhr, M.; Páez-Pereda, M.; Winter, G.; Hausch, F.; Chen, A.; Tschoep, M. H.; Rein, T.; Gassen, N. C.; Schmidt, M. V.: Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function. NATURE COMMUNICATIONS 8, 1725 (2017)

Uribe-Marino, A.; Gassen, N. C.; Wiesbeck, M. F.; Balsevich, G.; Santarelli, S.; Solfrank, B.; Dournes, C.; Fries, G. R.; Masana, M.; Labermaier, C. et al.; Wang, X.-D.; Hafner, K.; Schmid, B.; Rein, T.; Chen, A.; Deussing, J. M.; Schmidt, M. V.: Prefrontal Cortex Corticotropin-Releasing Factor Receptor 1 Conveys Acute Stress-Induced Executive Dysfunction. BIOLOGICAL PSYCHIATRY 80 (10), pp. 743 - 753 (2016)

Reichel, J. M.; Bedenk, B. T.; Gassen, N. C.; Hafner, K.; Bura, S. A.; Almeida-Correa, S.; Genewsky, A.; Dedic, N.; Giesert, F.; Agarwal, A. et al.; Nave, K. -.; Rein, T.; Czisch, M.; Deussing, J. M.; Wotjak, C. T.: Beware of Your Cre-Ation: lacZ Expression Impairs Neuronal Integrity and Hippocampus-Dependent Memory. HIPPOCAMPUS 26 (10), pp. 1250 - 1264 (2016)

Gassen, N. C.; Hartmann, J.; Zannas, A. S.; Kretzschmar, A.; Zschocke, J.; Maccarrone, G.; Hafner, K.; Zellner, A.; Kollmannsberger, L. K.; Wag, K. V. et al.; Mehta, D.; Kloiber, S.; Turck, C. W.; Lucae, S.; Chrousos, G. P.; Holsboer, F.; Binder, E. B.; Ising, M.; Schmidt, M. V.; Rein, T.: FKBP51 inhibits GSK3 beta and augments the effects of distinct psychotropic medications. MOLECULAR PSYCHIATRY 21 (2), pp. 277 - 289 (2016)

Gassen, N. C.; Fries, G. R.; Zannas, A. S.; Hartmann, J.; Zschocke, J.; Hafner, K.; Carrillo-Roa, T.; Steinbacher, J.; Preißinger, S. N.; Hoeijmakers, L. et al.; Knop, M.; Weber, F.; Kloiber, S.; Lucae, S.; Chrousos, G. P.; Carell, T.; Ising, M.; Binder, E. B.; Schmidt, M. V.; Ruegg, J.; Rein, T.: Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine. Science signaling 8 (404), p. ra119 - ra119 (2015)

Gassen, N. C.; Hartmann, J.; Zschocke, J.; Stepan, J.; Hafner, K.; Zellner, A.; Kirmeier, T.; Kollmannsberger, L.; Wagner, K. V.; Dedic, N. et al.; Balsevich, G.; Deussing, J. M.; Kloiber, S.; Lucae, S.; Holsboer, F.; Eder, M.; Uhr, M.; Ising, M.; Schmidt, M. V.; Rein, T.: Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans. PLOS MEDICINE 11 (11), e1001755 (2014)

Knapp, R. T.; Wong, M. J. H.; Kollmannsberger, L. K.; Gassen, N. C.; Kretzschmar, A.; Zschocke, J.; Hafner, K.; Young, J. C.; Rein, T.: Hsp70 Cochaperones HspBP1 and BAG-1M Differentially Regulate Steroid Hormone Receptor Function. PLOS ONE 9 (1), e85415 (2014)

Knapp, R. T.; Steiner, A.; Schmidt, U.; Hafner, K.; Holsboer, F.; Rein, T.: BAG-1 diversely affects steroid receptor activity. Biochemical Journal 441, pp. 297 - 303 (2012)