Gene by environment interaction as basis of depression

Depression is a complex psychiatric disorder that is thought to develop due to a combination of genetic risk factors with exposure to aversive environments. FKBP5, a co-chaperone of stress hormone receptors, seems to be a key mediator of depression, as polymorphisms in the gene encoding FKBP5 can increase the likelihood to develop this disease. By investigating the molecular, structural, physiological and behavioral function of FKBP5 we can support the central role of this co-chaperone in stress and depression, and pave the way for the development of novel antidepressant treatment strategies.